One of the most powerful antioxidants is vitamin E- and is now proven to be effective for mesothelioma patients. Antioxidants are known for their anti-cancer effects in the body as well as heart disease prevention, diabetes, PMS, muscle cramps, aging, arthritis, circulation problems, and some skin disorders.
It’s also critical for the immune system to work well. In utero, vitamin E is essential for the central nervous system to grow and develop correctly.
There are many different forms of vitamin E including:
• alpha-, beta-, gamma- and delta- tocopherol (the most active form in humans is alpha-tocopherol. The others are also active, decreasing in potency.)
• d- and dl-alpha-tocopheryl acetate
• d- and dl-alpha-tocopheryl succinate
• alpha, beta-, gamma- and delta- tocotrienol (considerably less widespread in the plant kingdom but found more commonly in GMO plants)
• dl- versions of the tocotrienols
Vitamin E Studies May Have Unexpected Results
Many researchers do experiments with vitamin E and end up getting mixed results. Much of the confusion in the studies on whether or not vitamin E works is most likely based on the form of vitamin E that is used in the study. For example, if it’s a natural form, it will be written as a d- form, whereas synthetic forms are written as dl-forms.
Vitamin E works at the mitochondrial level in the body, not the cellular level. This is why diabetics usually show high levels of Vitamin E in the blood, since their arterial plaques do not permit synthetic Vitamin E to get into the mitochondria. It’s also why some tests will show mixed results.
In the brain, only natural vitamin E can work; the synthetic form is ineffective. And synthetic vitamin E can even cause heart palpitations, whereas natural vitamin E does not.
Vitamin E can be esterified as well, and when it is, it’s the form d-alpha tocopheryl. When esterified, its antioxidant properties are sacrificed although it can still work well to keep blood moving and clot-free. Doses of 400 IU alpha-tocopherol per day provide greater than 75% inhibition of platelet adhesion to a variety of substances in the lab. This means they prevent clot formation. This is why mixed tocopherols or d-alpha-tocopherol are recommended when you need antioxidant effects.
Synthetic Forms of Vitamin E Used in Lab Tests
Dl-alpha-tocopheryl acetate and dl-alpha-tocopheryl succinate are the cheapest forms of vitamin E and they are the synthetic forms. They are the least effective forms.
Alpha-tocopherol can be natural or synthetic. If it’s natural, it’s usually found with a prefix of “RRR”. If it’s synthetic, it will be found on a label with the prefix “dl” or “all rac.” If you’re looking for a natural form, you can always count on d-alpha-tocopheryl.
Japanese Researchers Test Vitamin E for Mesothelioma
Researchers at Tokyo University, Chiba University, and Setsunan University in Japan tested vitamin E in their tissue cell lines of Malignant Mesothelioma. They wanted to see ho effective vitamin E was for mesothelioma cells- more specifically, killing or getting rid of them.
It didn’t take long to find out that the vitamin E really did cause the death of the malignant mesothelioma cells. This they confirmed so next they wanted to see whether or not the vitamin E affected the type of signaling in the body called Wnt signaling. This is the type of signaling that plays an essential role in the development of malignant mesothelioma tumor cell growth.
What they found was that the succinate ether derivative of alpha-tocotrienol alters the Wnt antagonist gene called Dickkopt-1(DKK1).
What Else is Known about Tocotrienols
The tocotrienol subfamily of vitamin E is known for its powerful neuroprotective, anti-cancer, and cholesterol lowering properties. Alpha-tocotrienol prevents neurodegeneration at nanomolar concentrations in studies.
Oral supplements of tocotrienol protects against stroke and very small amounts suppress the activity of the enzyme that makes cholesterol.
Here are some additional facts about tocotrienols:
• They reduce oxidative protein damage and extend life span.
• They are thought to have more potent antioxidant properties than alpha-tocopherol.
• Tocotrienol but not tocopherol suppresses the growth of human breast cancer cells.
• Tocotrienol restored fertility in animals where a long-term vitamin E deficiency caused infertility.
• Oral supplements of tocotrienol reaches the brain and protects against stroke.
• Tocotrienol is found in barley, the rubber latex plant, palm oil (30% tocopherols and 70% tocotrienols), rice bran oil, oat, rye, hulled and unhulled wheat, and oat groats.
The scientists stated that there were three ways that the vitamin E proves beneficial for mesothelioma cells. They believe that alpha-tocotrienol can cause death of malignant mesothelioma cells. At this time, doctors aren’t making any recommendations to mesothelioma patients.
- Sato, A., et al. A succinate ether derivative of tocotrienol enhances dickkopf-1 gene expression through epigenetic alterations in malignant mesothelioma cells. Pharmacology 2018;102(1-2):26-36.
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